Developmental time windows for axon growth influence neuronal network topology
نویسندگان
چکیده
منابع مشابه
Developmental time windows for spatial growth generate multiple-cluster small-world networks
Many networks extent in space, may it be metric (e.g. geographic) or non-metric (ordinal). Spatial network growth, which depends on the distance between nodes, can generate a wide range of topologies from small-world to linear scale-free networks. However, networks often lacked multiple clusters or communities. Multiple clusters can be generated, however, if there are time windows during develo...
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Axon growth is a highly regulated process that requires stimulating signals from extracellular factors. The extracellular signals are then transduced to regulate coordinately gene expression and local axon assembly. Growth factors, especially neurotrophins that act via receptor tyrosine kinases, have been heavily studied as extracellular factors that stimulate axon growth. Downstream of recepto...
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Recent advances in defining neurotrophin signaling mediators have provided insights into the signal transduction mechanisms that underlie axon growth. Evidence is accumulating that major Trk effectors regulate the morphological development of embryonic peripheral neurons. Less is known about signaling related to the robust axon extension that follows peripheral axotomy of adult neurons. Regener...
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ژورنال
عنوان ژورنال: Biological Cybernetics
سال: 2015
ISSN: 0340-1200,1432-0770
DOI: 10.1007/s00422-014-0641-3